Sanders has had a long career in film and TV, but is probably most recognized for his work in the blockbuster films The Day After Tomorrow and Green Lantern. Sanders is also noted for playing Mob lawyer character Steven Kordo in the 1986–88 NBC detective series Crime Story. He is also known as the narrator for the PBS series Wide Angle from 2002–2009 and has served as narrator for a number of Nova episodes starting in 2007. On stage he has appeared on Broadway in Loose Ends, The Caine Mutiny Court-Martial, Saint Joan, and Pygmalion. Off-Broadway, he appeared as George W. Bush in David Hare's Stuff Happens in 2006 and the title role in Shakespeare's Titus Andronicus.